Biofunctionalization with hyaluronic acid

impact on dental regeneration

In this webinar, Prof. Anton Sculean, the leading expert in the use of hyaluronic acid in regenerative dentistry will present and discuss the biologic principles and rationale of using hyaluronic acid with a special focus on periodontal applications. The use of cerabone® plus within the scope of aesthetic implant dentistry and different GBR procedures will be presented by Dr. Marius Steigmann. Dr. Dragana Rakasevic from the University of Belgrade will provide insights into a running randomized controlled clinical trial on the therapy of periimplantitis lesions. Implementation of cerabone® plus into his concept of slow dentistry and insights into how his clinical routine has been facilitated will be presented by Dr. Miguel Stanley.


Usability and clinical manageability are emerging key aspects when it comes to the requirements for the ‘ideal’ bone grafting material. Handling characteristics of bone regeneration materials can be significantly improved by organic additives, with hyaluronic acid being most recently introduced. Hyaluronic acid as an important component of hard and soft tissues has increasingly attracted attention in many medical applications, not only because of its biological activities but also due to its liquid binding capacities.


The use of bovine bone materials has a long tradition, is very well documented and has a high acceptance worldwide. cerabone® is a 100% pure bone mineral of bovine origin produced by a unique 1200°C manufacturing process for maximum safety. This processing results in reduced solubility and high crystallinity, which in turn leads to excellent volumetric stability. cerabone® has been successfully used in regenerative dental medicine in over 2 million patients and more than 200 publications prove its unique material characteristics and clinical efficacy.


cerabone® plus is composed of the established bovine bone substitute material cerabone® and the biopolymer sodium hyaluronate. Upon hydration, this combination results in a bone substitute material with exceptional volume stability and the well-known biological properties of hyaluronic acid. Thanks to the remarkable liquid binding capacity of the hyaluronate in cerabone® plus, a viscous solution forms upon contact with aqueous solutions and blood. The malleable mass of cerabone® plus allows for efficient defect augmentation, time saving application, as well as easy defect contouring. At the same time, single particle displacement is reduced.

Dr. Marius Steigmann


Prof. Dr. Anton Sculean


Dr. Dragana Rakasevic


Dr. Miguel Stanley