mucoderm®

ACELLULAR DERMAL COLLAGEN MATRIX

 

mucoderm® is an acellular collagen matrix that offers a safe alternative to autologous soft tissue transplants in a diverse range of soft tissue grafting indications. mucoderm® is derived from porcine dermis that undergoes a multi-step purification process, which removes all non-collagenous proteins and cells as well as potential immunogens, bacteria and viruses. The processing results in a three-dimensional stable matrix, which consists of collagen type I and III with a natural collagen structure that resembles the human connective tissue [1]. After implantation mucoderm® is continuously remodeled into patients own soft tissue.

 

SPECIFICATIONS & FACTS

SCAFFOLD FOR INGROWING CELLS AND VESSELS

 

mucoderm® shows a high interconnected porosity and native collagen structure making it an excellent scaffold for ingrowing blood vessels and cells, thus supporting a fast revascularization and tissue integration [5]. Attracted by the signals of activated migrating and proliferating endothelial cells, blood vessels from the surrounding tissue will grow into the matrix. At the same time, fibroblasts adhere and spread onto the matrix. The simultaneous degradation of the matrix and the collagen production of adhering fibroblasts leads to a complete substitution of mucoderm® by the newly formed host tissue within about 6-9 months [3].

CLINICAL APPLICATION

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PROPERTIES

– Rapid revascularization and tissue integration
– Soft tissue regeneration/augmentation without palatal autograft harvesting
– Complete remodeling into patient’s own tissue in ~6-9 months
– Can be easily applied and fixed by sutures
– Can be cut into procedure-specific shapea

INDICATIONS

mucoderm® can be applied as an alternative to autologous soft tissue transplants such as connective tissue graft (CTG) and free gingival graft (FGG) in certain indication in periodontology and implantology. The use of muocderm® is of particular advantage in situations where autologous transplants cannot be harvested in sufficient amount or quality (e.g. in thin biotype, shallow palate or covering of multiple recessions) or if patients are afraid of and do not agree with a tissue harvesting.

IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF

– Treatment of gingival recessions
Soft tissue grafting in combination with GBR/GTR
Broadening of attached gingiva (instead of FGG)
Closure of extraction sockets (socket seal technique)
– Thickening of periimplant soft tissue

PRODUCT INFORMATION

botiss ACADEMY

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LITERATURE

[1] Ramachandra SS, Rana R, Reetika S, Jithendra KD. Options to avoid the surgical site: a review of literature. Cell Tissue Bank Bank 2014, 15(3): 297-305.
[2] Pabst AM, Wagner W, Kasaj A, Gebhardt S, Ackermann M, Astolfo A, Marone F, Haberthür D, Enzmann F, Konerding M A. Synchrotronbased X-ray tomographic microscopy for visualization of three-dimensional collagen matrices. Clin Oral Investig 2015, 19(2):561-4.
[3] Rothamel D, Benner M, Fienitz T, Happe A, Kreppel M, Nickenig HJ and Zöller JE Biodegradation pattern and tissue integration of native and cross-linked porcine collagen soft tissue augmentation matrices – an experimental study in the rat. Head and Face 2014, 10:10.
[4] Kasaj A, Levin L, Stratul SI, Götz H, Schlee M, Rütters CB, Konerding MA, Ackermann M, Willershausen B, Pabst AM.The influence of various rehydration protocols on biomechanical properties of different acellular tissue matrices. Clin Oral Invest. 2015.
[5] Pabst AM, Happe A, Callaway A, Ziebart T, Stratul SI, Ackermann M, Konerding MA, Willershausen B, Kasaj A. In vitro and in vivo characterization of porcine acellular dermal matrix for gingival augmentation procedures. Periodont Res. 2014, 49(3): 37-81
[6] Mörmann W, Ciancio SG. Blood supply of human gingiva following periodontal surgery. A fluorescein angiographic study. J Periodontol. 1977 Nov;48(11):681-92