Jason® fleece

RESORBABLE COLLAGEN FOR WOUND MANAGEMENT

Jason® fleece is a pH-neutral, wet-stable, porcine collagen sponge with highly efficient hemostatic properties [1,2]. Its natural porous collagen structure supports the hemostasis and controls the natural healing of the wound. Owing to its spongy collagen structure, the Jason® fleece resorbs within ~2-4 weeks.

SPECIFICATIONS & FACTS

FAST HEMOSTASIS AND STABILIZATION OF THE BLOOD CLOT

The efficacy of Jason® fleece is based on the well-known characteristics of collagen. The process of blood clotting comprises a complex series of reactions induced by the adhesion of platelets to the collagen fibers, which results in the formation of a thrombus by platelet aggregation. The secretion of coagulation factors is thereby triggered, which initiate further reactions as the formation of a fibrin clot [3,4,5]. The fast clotting reaction through Jason® fleece is particularly helpful when treating hemostatic compromised patients [6].

PROPERTIES

– pH-neutral
Highly efficient hemostatic collagen
Fast resorption by enzymatic degradation (2-4 weeks)
Easy application
Maintains integrity in presence of blood and during application
Wound protection/wound healing

 

INDICATIONS

Jason® fleece is indicated as a hemostatic agent for e.g. arterial and diffuse seeping bleedings especially in situations in which the application of conventional hemorrhage agents are challenging and time-consuming.

IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY

– Minor oral wounds
Coverage of augmentation sites
Protection of the Schneiderian membrane
Biopsy sites

POSTER/ARTICLE:

  • Calvo-Guirado JL, Ramírez-Fernández MP, Delgado-Ruíz RA, Maté-Sánchez JE, Velasquez P, de Aza PN. Influence of biphasic β-TCP with and without the use of collagen membranes on bone healing of surgically critical size defects. A radiological, histological, and histomorphometric study. Clin Oral Implants Res. 2014;25(11):1228-38. LINK
  • Kilian O, Hossain H, Flesch I, Sommer U, Nolting H, Chakraborty T, Schnettler R. Elution kinetics, antimicrobial efficacy, and degradation and microvasculature of a new gentamicin-loaded collagen fleece. J Biomed Mater Res B Appl Biomater. 2009; 90(1):210-22. LINK
  • Ozcelik O, Seydaoglu G, Haytac CM. Diode laser for harvesting de-epithelialized palatal graft in the treatment of gingival recession defects: a randomized clinical trial. J Clin Periodontol. 2016; 43(1):63-71. LINK
  • Steigmann M, Daum O, Kaiser C. Active manipulation of the soft tissue. EDI Journal 4/2014. P.44. LINK
  • Zirk M, Fienitz T, Edel R, Kreppel M, Dreiseidler T, Rothamel D. Prevention of post-operative bleeding in hemostatic compromised patients using native porcine collagen fleeces-retrospective study of a consecutive case series. Oral Maxillofac Surg. 2016. [Epub ahead of print]. LINK

RELATED PRODUCTS

LITERATURE

[1] Kilian O, Hossain H, Flesch I, Sommer U, Nolting H, Chakraborty T, Schnettler R. Elution kinetics, antimicrobial efficacy, and degradation and microvasculature of a new gentamicin-loaded collagen fleece. J Biomed Mater Res B Appl Biomater. 2009; 90(1):210-22.
[2] Fleege C, Schmidt J, Schmidt I, Zukowski D, Rauschmann M. Efficacy and biocompatibility of Jason® collagen fleece for haemostasis after iliac crest harvesting of autologous cancellous bone- an observational clinical study. European Mucoskeletal Review 2012; 7(4):240-2.
http://www4.asklepios.com/asklepiosCMS/webpageUpload/746501148__2012_Europ_Musc_Res_Jason.pdf
[3] Nieswandt B and Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003; 15;102(2):449-61. http://www.ncbi.nlm.nih.gov/pubmed/12649139
[4] Nuyttens BP, Thijs T, Deckmyn H, Broos K. Platelet adhesion to collagen. Thromb Res. 2011; 127 Suppl 2:S26-9. http://www.ncbi.nlm.nih.gov/pubmed/21193111
[5] Versteeg H.H, Heemskerk J.W.M, Levi M, Reitsma P.H. New fundamentals in hemostasis. Physiological Reviews 2013; 93(1): 327-358.
[6] Zirk et al. Prevention of post-operative bleeding in hemostatic compromised patients using native porcine collagen fleeces-retrospective study of a consecutive case series. Oral Maxillofac Surg. 2016. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/27139018[7] Morimotot et al. 2008. Hemostatic management of tooth extractions in patients on oral antithrombotic therpy. J Maxillofacial Surg 66:51.