RESORBABLE COLLAGEN FOR WOUND MANAGEMENT
Jason® fleece is a pH-neutral, wet-stable, porcine collagen sponge with highly efficient hemostatic properties [1,2]. Its natural porous collagen structure supports the hemostasis and controls the natural healing of the wound. Owing to its spongy collagen structure, the Jason® fleece resorbs within ~2-4 weeks.
FAST HEMOSTASIS AND STABILIZATION OF THE BLOOD CLOT
The efficacy of Jason® fleece is based on the well-known characteristics of collagen. The process of blood clotting comprises a complex series of reactions induced by the adhesion of platelets to the collagen fibers, which results in the formation of a thrombus by platelet aggregation. The secretion of coagulation factors is thereby triggered, which initiate further reactions as the formation of a fibrin clot [3,4,5]. The fast clotting reaction through Jason® fleece is particularly helpful when treating hemostatic compromised patients .
– Highly efficient hemostatic collagen
– Fast resorption by enzymatic degradation (2-4 weeks)
– Easy application
– Maintains integrity in presence of blood and during application
– Wound protection/wound healing
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Jason® fleece is indicated as a hemostatic agent for e.g. arterial and diffuse seeping bleedings especially in situations in which the application of conventional hemorrhage agents are challenging and time-consuming.
IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY
– Minor oral wounds
– Coverage of augmentation sites
– Protection of the Schneiderian membrane
– Biopsy sites
- Calvo-Guirado JL, Ramírez-Fernández MP, Delgado-Ruíz RA, Maté-Sánchez JE, Velasquez P, de Aza PN. Influence of biphasic β-TCP with and without the use of collagen membranes on bone healing of surgically critical size defects. A radiological, histological, and histomorphometric study. Clin Oral Implants Res. 2014;25(11):1228-38. LINK
- Kilian O, Hossain H, Flesch I, Sommer U, Nolting H, Chakraborty T, Schnettler R. Elution kinetics, antimicrobial efficacy, and degradation and microvasculature of a new gentamicin-loaded collagen fleece. J Biomed Mater Res B Appl Biomater. 2009; 90(1):210-22. LINK
- Ozcelik O, Seydaoglu G, Haytac CM. Diode laser for harvesting de-epithelialized palatal graft in the treatment of gingival recession defects: a randomized clinical trial. J Clin Periodontol. 2016; 43(1):63-71. LINK
- Steigmann M, Daum O, Kaiser C. Active manipulation of the soft tissue. EDI Journal 4/2014. P.44. LINK
- Zirk M, Fienitz T, Edel R, Kreppel M, Dreiseidler T, Rothamel D. Prevention of post-operative bleeding in hemostatic compromised patients using native porcine collagen fleeces-retrospective study of a consecutive case series. Oral Maxillofac Surg. 2016. [Epub ahead of print]. LINK
 Kilian O, Hossain H, Flesch I, Sommer U, Nolting H, Chakraborty T, Schnettler R. Elution kinetics, antimicrobial efficacy, and degradation and microvasculature of a new gentamicin-loaded collagen fleece. J Biomed Mater Res B Appl Biomater. 2009; 90(1):210-22.
 Fleege C, Schmidt J, Schmidt I, Zukowski D, Rauschmann M. Efficacy and biocompatibility of Jason® collagen fleece for haemostasis after iliac crest harvesting of autologous cancellous bone- an observational clinical study. European Mucoskeletal Review 2012; 7(4):240-2.
 Nieswandt B and Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003; 15;102(2):449-61. http://www.ncbi.nlm.nih.gov/pubmed/12649139
 Nuyttens BP, Thijs T, Deckmyn H, Broos K. Platelet adhesion to collagen. Thromb Res. 2011; 127 Suppl 2:S26-9. http://www.ncbi.nlm.nih.gov/pubmed/21193111
 Versteeg H.H, Heemskerk J.W.M, Levi M, Reitsma P.H. New fundamentals in hemostasis. Physiological Reviews 2013; 93(1): 327-358.
 Zirk et al. Prevention of post-operative bleeding in hemostatic compromised patients using native porcine collagen fleeces-retrospective study of a consecutive case series. Oral Maxillofac Surg. 2016. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/27139018 Morimotot et al. 2008. Hemostatic management of tooth extractions in patients on oral antithrombotic therpy. J Maxillofacial Surg 66:51.