Preclinical study analyzed the bone graft integration and angiogenesis after augmentation with cerabone®

Inflammatory-driven angiogenesis in bone augmentation with bovine hydroxyapatite, B-tricalcium phosphate and Bioglasses. Comparative study.
Anghelescu V, Neculae I, Dinca O, Vladan C, Socoliuc C, Cioplea M, Nichita L, Popp C, Zurac S, and Bucur A. Journal of Immunology Research. July 2018.

Anghelescu and colleagues studied the inflammatory-reduced angiogenesis after augmentation with different biomaterials and the resulting integration potential of the materials.

Tibadefects in rabbits were augmented with either cerabone®, a pure beta-TCP or Bioglass. After a healing period of six months biopsies were harvested and immunhistochemically analysed. Angiogenesis and bone remodeling were determined with the help of different marker molecules.

The results showed a significantly higher bone formation around beta-TCP and cerabone® particles compared to Bioglass. Furthermore, a higher formation of vessels and higher vessel lumen was observed. The results indicated a tendency towards better activity of cerabone® comparing with beta-TCP.

The authors concluded that cerabone® provides a matrix that supports the formation of capillaries and due to its osteoconductive properties facilitates new bone formation.

V. Anghelescu


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