In vitro evaluation of an injectable biphasic calcium phosphate (BCP) carrier system combined with recombinant human bone morphogenetic protein (rhBMP)-9.
Bio-Medical Materials and Engineering 28 (2017) 293–304.
Fujioka-Kobayashi et al.
Study aim and design:
The study evaluated the possibility of combining maxresorb® inject with growth factors by analyzing adsorption of rhBMP9 as well as adhesion, proliferation, viability and differentiation of stromal cells.
The results demonstrated that maxresorb inject serves as an excellent carrier for the growthfactors. The bone paste showed very good adsorption/retention potential of rhBMP9 with a slow and steady release over a 10 day period. The combination of maxresorb® inject and rhBMP9 demonstrated a good osteoinductive potential by positively influencing the osteoblastic differentiation of stromal cells.