1200°C SAFETY

free of chemical additives

The unique manufacturing process enables a slow and sustained heating of the bone up to >1200°C for maximum safety.
> THE PROCESS

ROUGH HYDROPHILIC
SURFACE

100% PURE bone mineral

DEPOT-EFFECT & Bioactive surface


The interconnected pores and superior hydrophilic surface of cerabone® support the adhesion of proteins from the blood. cerabone® binds and gradually releases signaling molecules thereby providing a long-term depot-effect1. In addition, the 100 % pure natural bone mineral acts as a calcium reservoir slowly releasing calcium ions important for bone remodeling2.

the purest volume stable bovine bone graft

> OSSEOUS CELLULAR INTEGRATION

THREE-
DIMENSIONAL
PORE NETWORK
Human-like bone structure

Ultimate VOLUME STABILITY

Regeneration through integration

The reduced solubility of pure bone apatite and the high crystallinity of cerabone® result in excellent mechanical and biological stability.
> EVIDENCE

The purest volume stable bovine bone graft

> 1 Million

patients treated

15 years

clinical experience in various medical applications

> 90

countries

> 150

scientific contributions

cerabone® is a 100% pure bone mineral of bovine origin manufactured by a unique 1200°C production process. It possesses a three-dimensional pore network and rough, hydrophilic surface that allows fast penetration and adsorption of blood and serum proteins. The sophisticated processing of the bovine bone removes all organic components resulting in a bone mineral with exceptional purity3. In addition, potential infectious agents such as bacteria, viruses and prions are removed through the high temperature treatment processing4. Both product and production process are fulfilling applicable national and international regulatory and safety requirements for bovine bone grafts including ISO 22422-1, ISO 22442-2 and ISO 22442-3.

 

UNIQUE
PRODUCTION PROCESS
> MAXIMUM SAFETY

100% PURE
BONE MINERAL

BIOACTIVE SURFACE
& DEPOT-EFFECT

SUPERIOR
HYDROPHILICITY

ULTIMATE
VOLUME STABILITY

REFERENCES

1 In vitro experiments from Prof. Dr. H. Jennissen and Dr. M. Laub University of Duisburg-Essen/Morphoplant GmbH

2 Berberi A, Samarani A, Nader N, Noujeim Z, Dagher M, Kanj W, Rita Mearawi,1 Ziad Salemeh,1 and Bassam Badran2 Physicochemical characteristics of bone substitutes used in oral surgery in comparison to autogenous bone. Biomed Res Int. 2014;2014:320790.

3 Tadic, D. and Epple, M. (2004), “A thorough physicochemical characterisation of 14 calcium phosphate-based bone substitution materials in comparison to natural bone”, Biomaterials, Vol. 25 No. 6, pp. 987–994.

4 Brown, P., Rau, E.H., Johnson, B.K., Bacote, A.E., Gibbs, C.J. and Gajdusek, D.C. (2000), New studies on the heat resistance of hamster-adapted scrapie agent: threshold survival after ashing at 600 degrees C suggests an inorganic template of replication, PNAS, Vol. 97 No. 7, pp. 3418–3421.